NAIP Antibody

Size

100ug

Clone Number

Aliases

Baculoviral IAP repeat containing 1 antibody; Baculoviral IAP repeat-containing protein 1 antibody; BIRC 1 antibody; BIRC1 antibody; BIRC1_HUMAN antibody; Birc1a antibody; FLJ42520 antibody; NAIP antibody; Naip1 antibody; Neuronal apoptosis inhibitory protein antibody; NLR family apoptosis inhibitory protein antibody; NLR family BIR domain containing 1 antibody; NLRB 1 antibody; NLRB1 antibody; Nucleotide binding oligomerization domain leucine rich repeat and BIR domain containing 1 antibody; Psi neuronal apoptosis inhibitory protein antibody; psiNAIP antibody; Similar to occludin antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13075

Immunogen

Recombinant Human Baculoviral IAP repeat-containing protein 1 protein (147-242AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200

Background

\\\"Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at \\\'Asp-315\\\' and decreasing the rate of auto proteolysis at \\\'Asp-330\\\'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.\\\"

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NAIP

Research Areas

Cell Biology