MYPT1/2(Phospho Ser668/Ser618) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

Regulates myosin phosphatase activity.|PTM:Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage| probably by ATM or ATR.|sequence Contaminating sequence. Potential poly-A sequence.|Contains 6 ANK repeats.|subcellular location:Along actomyosin filaments and stress fibers.|subunit:PP1 comprises a catalytic subunit| PPP1CA| PPP1CB or PPP1CC| and one or several targeting or regulatory subunits. PPP1R12A mediates binding to myosin. Interacts with ARHA and CIT (By similarity). Binds PPP1R12B| ROCK1 and IL16.|

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human MYPT1/2 (Phospho Ser668/Ser618)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

113300

synonyms

MYPT1/2 ;Phospho Ser668/Ser618; Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase-targeting subunit 1; Myosin phosphatase target subunit 1; Protein phosphatase myosin-binding subunit