MYOC Antibody

Size

100ug

Clone Number

Aliases

GLC1A antibody; GPOA antibody; JOAG antibody; JOAG1 antibody; Mutated trabecular meshwork-induced glucocorticoid response protein antibody; MYOC antibody; MYOC_HUMAN antibody; Myocilin antibody; Myocilin, trabecular meshwork inducible glucocorticoid antibody; TIGR antibody; Trabecular meshwork induced glucocorticoid response protein antibody; Trabecular meshwork-induced glucocorticoid response protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q99972

Immunogen

Recombinant Human Myocilin protein (183-294AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500

Background

Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

MYOC

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience