MSL2 Antibody

Size

100ug

Clone Number

Aliases

Male specific lethal 2 homolog (Drosophila) antibody; Male specific lethal 2 homolog 1 antibody; Male specific lethal 2 homolog antibody; Male specific lethal 2 like 1 antibody; Male-specific lethal 2 homolog antibody; Male-specific lethal 2-like 1 antibody; Male-specific lethal-2 homolog 1 antibody; MSL-2 antibody; MSL2 antibody; MSL2-like 1 antibody; MSL2_HUMAN antibody; MSL2L1 antibody; Ring finger protein 184 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9HCI7

Immunogen

Recombinant Human E3 ubiquitin-protein ligase MSL2 protein (341-473AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at \\\'Lys-35\\\' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at \\\'Lys-4\\\' (H3K4me) and \\\'Lys-79\\\' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

MSL2

Research Areas

Epigenetics and Nuclear Signaling