MSH6 Monoclonal Antibody

Size

100ug

Clone Number

2C12F3

Aliases

MutS Homolog 6,GTBP,HSAP2,DNA Mismatch Repair Protein Msh6,G/T Mismatch-Binding Protein

Immunogen Species

Human

UniProt ID

P52701

Immunogen

Recombinant Human MSH6 Protein

Raised in

Mouse

Species Reactivity

Human

Tested Applications

ELISA,IHC;Recommended dilution:IHC:1:50-1:500

Background

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa,called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have beendescribed.

Clonality

Monoclonal

Isotype

IgG

Purification Method

>95%,Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

MSH6

Research Areas

Epigenetics and Nuclear Signaling