MRCKG Polyclonal Antibody

Ab type

Primary antibody

Background

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation.,May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.,Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.,Contains 1 AGC-kinase C-terminal domain.,Contains 1 CNH domain.,Contains 1 CRIB domain.,Contains 1 PH domain.,Contains 1 phorbol-ester/DAG-type zinc finger.,Contains 1 protein kinase domain.,subcellular location:Concentrates at the leading edge of cells.,subunit:Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42.,tissue specificity:Expressed in heart and skeletal muscle.,

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human protein . at AA range: 1370-1450

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

Serine/threonine-protein kinase MRCK gamma ;EC 2.7.11.1;CDC42-binding protein kinase gamma;DMPK-like gamma;Myotonic dystrophy kinase-related CDC42-binding kinase gamma;MRCK gamma;MRCKG;Myo