MORF4L1 Antibody

Size

100ul

Clone Number

Aliases

CG6363 antibody; Eaf3 antibody; Esa1p associated factor 3 homolog antibody; FWP006 antibody; HsT17725 antibody; MEAF3 antibody; MO4L1_HUMAN antibody; MORF related gene on chromosome 15 antibody; MORF-related gene 15 protein antibody; Morf4l1 antibody; MORFRG15 antibody; Mortality factor 4 like 1 antibody; Mortality factor 4 like protein 1 antibody; Mortality factor 4-like protein 1 antibody; MRG15 antibody; Protein MSL3-1 antibody; S863-6 antibody; Transcription factor-like protein MRG15 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UBU8

Immunogen

Recombinant Human Mortality factor 4-like protein 1 protein (1-100AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

MORF4L1

Research Areas

Epigenetics and Nuclear Signaling; Cancer