MLTK Polyclonal Antibody

Ab type

Primary antibody

Background

MLTK is a member of the MAPKKK family of signal transduction molecules and encodes a protein, Mitogen-activated protein kinase kinase kinase MLT, with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Reactivity

Human;Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human ZAK. AA range:131-180

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

91181

synonyms

MLTK; ZAK; HCCS4; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitog