MLCK(Phospho Tyr471) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene| a muscle member of the immunoglobulin gene superfamily| encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition| using a separate promoter in an intron in the 3' region| it encodes telokin| a small protein identical in sequence to the C-terminus of myosin light chain kinase| that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human MLCK (Phospho Tyr471)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

210540

synonyms

MLCK ;Phospho Tyr471; Myosin light chain kinase; smooth muscle; MLCK; smMLCK; EC 2.7.11.18; Kinase-related protein; KRP; Telokin; Myosin light chain kinase; smooth muscle; deglutamylated form;