MICU1 Antibody

Size

100ug

Clone Number

Aliases

Allergen Hom s 4 antibody; ara CALC antibody; atopy related autoantigen antibody; atopy related autoantigen CALC antibody; Atopy-related autoantigen CALC antibody; CALC antibody; calcium binding atopy related autoantigen 1 antibody; Calcium uptake protein 1 antibody; calcium uptake protein 1, mitochondrial antibody; Calcium-binding atopy-related autoantigen 1 antibody; CBARA1 antibody; EFHA3 antibody; FLJ12684 antibody; MICU1 antibody; MICU1_HUMAN antibody; mitochondrial antibody; mitochondrial calcium uptake 1 antibody; MPXPS antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BPX6

Immunogen

Recombinant Human Calcium uptake protein 1, mitochondrial protein (55-191AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500

Background

Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

MICU1

Research Areas

Immunology; Metabolism; Signal transduction