MFN2 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

CMT2A antibody; CMT2A2 antibody; CPRP 1 antibody; CPRP1 antibody; EC 3.6.5.- antibody; Fzo antibody; HSG antibody; hyperplasia suppressor gene antibody; Hypertension related protein 1 antibody; KIAA0214 antibody; MARF antibody; MFN 2 antibody; Mfn2 antibody; MFN2_HUMAN antibody; Mitochondrial assembly regulatory factor antibody; Mitofusin-2 antibody; Mitofusin2 antibody; Transmembrane GTPase MFN2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O95140

Immunogen

Recombinant Human Mitofusin-2 protein (61-158AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

MFN2

Research Areas

Neuroscience; Cancer; Cell biology; Tags & Cell Markers; Metabolism; Signal transduction