METTL14 Antibody

Size

100ul

Clone Number

Aliases

KIAA1627 antibody; MET14_HUMAN antibody; Methyltransferase like 14 antibody; Methyltransferase-like protein 14 antibody; METTL14 antibody; N6-adenosine-methyltransferase subunit METTL14 antibody; OTTHUMP00000219837 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9HCE5

Immunogen

Recombinant Human N6-adenosine-methyltransferase subunit METTL14 protein (24-206AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and differentiation of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5\'-[AG]GAC-3\' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing and mRNA stability (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop. M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

METTL14

Research Areas

Cell biology