Metrnl Antibody

Size

100ug

Clone Number

Aliases

MetrnlMeteorin-like protein antibody; Subfatin antibody

Immunogen Species

Mus musculus (Mouse)

UniProt ID

Q8VE43

Immunogen

Recombinant Mouse Meteorin-like protein (46-311AA)

Raised in

Rabbit

Species Reactivity

Mouse, Rat

Tested Applications

ELISA, WB; Recommended dilution: WB:1:200-1:2000

Background

Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

Metrnl

Research Areas

Others