MERTK Antibody

Size

100ul

Clone Number

Aliases

c MER antibody; c mer proto oncogene tyrosine kinase antibody; c-mer antibody; cMER antibody; cmer protooncogene tyrosine kinase antibody; Eyk antibody; MER antibody; MER receptor tyrosine kinase antibody; MERK antibody; MERPEN antibody; Mertk antibody; MERTK c-mer proto-oncogene tyrosine kinase antibody; MERTK_HUMAN antibody; MGC133349 antibody; nmf12 antibody; Nyk antibody; Proto oncogene tyrosine protein kinase MER antibody; Proto oncogene tyrosine protein kinase MER precursor antibody; Proto-oncogene c-Mer antibody; Receptor tyrosine kinase MerTK antibody; RP38 antibody; STK kinase antibody; Tyrosine-protein kinase Mer antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q12866

Immunogen

Recombinant Human Tyrosine-protein kinase Mer protein (840-999AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

Background

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

MERTK

Research Areas

Neuroscience; Signal transduction