MEOX1 Antibody

Size

100ul

Clone Number

Aliases

Homeobox protein MOX-1 antibody; MEOX1 antibody; MEOX1_HUMAN antibody; Mesenchyme homeo box 1 antibody; Mesenchyme homeobox 1 antibody; MOX 1 antibody; MOX1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P50221

Immunogen

Recombinant Human Homeobox protein MOX-1 protein (1-254AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

MEOX1

Research Areas

Epigenetics and Nuclear Signaling; Cell biology; Developmental biology; Stem cells