MEL-1A-R Polyclonal Antibody

Ab type

Primary antibody

Background

MTNR1A encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human MTR1A. AA range:191-240

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

39375

synonyms

MTNR1A; Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor