MEF2A Antibody

Size

100ul

Clone Number

Aliases

ADCAD1 antibody; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) antibody; MEF2 antibody; MEF2A antibody; MEF2A_HUMAN antibody; Myocyte enhancer factor 2A antibody; Myocyte-specific enhancer factor 2A antibody; RSRFC4 antibody; RSRFC9 antibody; Serum response factor like protein 1 antibody; Serum response factor-like protein 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q02078

Immunogen

Recombinant Human Myocyte-specific enhancer factor 2A protein (72-226AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB; Recommended dilution: WB:1:100-1:1000

Background

Transcriptional activator which binds specifically to the MEF2 element, 5\'-YTA[AT](4)TAR-3\', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

MEF2A

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience; Cardiovascular; Signal transduction; Stem cells