MDM2 Polyclonal Antibody

Ab type

Primary antibody

Background

MDM2 encodes a nuclear-localized E3 ubiquitin ligase. E3 ubiquitin-protein ligase Mdm2 can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from the C-terminal region of human MDM2. AA range:381-430

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

55233

synonyms

MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2