MDC1 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

Homologue to Drosophila photoreceptor protein calphotin antibody; MDC 1 antibody; Mdc1 antibody; MDC1_HUMAN antibody; Mediation of DNA damage checkpoint 1 antibody; Mediator of DNA damage checkpoint 1 antibody; Mediator of DNA damage checkpoint protein 1 antibody; NFBD 1 antibody; NFBD1 antibody; Nuclear factor with BRCT domains 1 antibody; Nuclear Factor with BRCT Domains Protein 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q14676

Immunogen

Recombinant Human Mediator of DNA damage checkpoint protein 1 protein (1892-2082AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by \'Ser-139\' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

MDC1

Research Areas

Epigenetics and Nuclear Signaling