MCT8 Polyclonal Antibody

Ab type

Primary antibody

Background

SLC16A2 (solute carrier family 16 member 2) encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). SLC16A2 is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in SLC16A2 are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. SLC16A2 is subject to X-chromosome inactivation. Mutations in SLC16A2 are the cause of Allan-Herndon-Dudley syndrome.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human SLC16A2. AA range:112-161

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

59511

synonyms

SLC16A2; MCT8; XPCT; Monocarboxylate transporter 8; MCT 8; Monocarboxylate transporter 7; MCT 7; Solute carrier family 16 member 2; X-linked PEST-containing transporter