MAPK7 Antibody

Size

100ul

Clone Number

Aliases

Big MAP kinase 1 antibody; BMK 1 antibody; BMK 1 kinase antibody; BMK-1 antibody; BMK1 antibody; BMK1 Kinase antibody; EC 2.7.11.24 antibody; ERK 4 antibody; ERK 5 antibody; ERK-5 antibody; ERK4 antibody; ERK5 antibody; Extracellular signal regulated kinase 5 antibody; Extracellular signal-regulated kinase 5 antibody; MAP kinase 7 antibody; MAPK 7 antibody; MAPK7 antibody; Mitogen activated protein kinase 7 antibody; Mitogen-activated protein kinase 7 antibody; MK07_HUMAN antibody; OTTHUMP00000065906 antibody; OTTHUMP00000065907 antibody; PRKM 7 antibody; PRKM7 antibody; PROTEIN KINASE; MITOGEN-ACTIVATED; 7 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13164

Immunogen

Recombinant Human Mitogen-activated protein kinase 7 protein (1-310AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

MAPK7

Research Areas

Neuroscience; Signal transduction