LY9 Antibody

Size

100ul

Clone Number

Aliases

CD229 antibody; Cell surface molecule Ly-9 antibody; Cell surface molecule Ly9 antibody; hly9 antibody; LY 9 antibody; Ly9 antibody; LY9_HUMAN antibody; Lymphocyte antigen 9 antibody; mLY9 antibody; Signaling lymphocytic activation molecule 3 antibody; SLAM family member 3 antibody; SLAMF3 antibody; T lymphocyte surface antigen Ly9 precursor antibody; T-lymphocyte surface antigen Ly-9 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9HBG7

Immunogen

Recombinant Human T-lymphocyte surface antigen Ly-9 protein (160-360AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LY9

Research Areas

Immunology; Stem cells