LRRK2 Antibody

Size

100ug

Clone Number

Aliases

augmented in rheumatoid arthritis 17 antibody; AURA17 antibody; Dardarin antibody; Leucine rich repeat kinase 2 antibody; leucine rich repeat serine threonine protein kinase 2 antibody; Leucine-rich repeat serine/threonine-protein kinase 2 antibody; LRRK 2 antibody; LRRK2 antibody; LRRK2_HUMAN antibody; PARK 8 antibody; PARK8 antibody; RIPK7 antibody; ROCO 2 antibody; ROCO2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q5S007

Immunogen

Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 2 protein (2029-2275AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LRRK2

Research Areas

Neuroscience