LRRK2 Antibody

Size

100ul

Clone Number

4E9

Aliases

Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin), LRRK2, PARK8

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q5S007

Immunogen

A synthesized peptide derived from human LRRK2

Raised in

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:50-1:200

Background

Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.

Clonality

Monoclonal

Isotype

Rabbit IgG

Purification Method

Affinity-chromatography

Conjugate

Non-conjugated

Buffer

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LRRK2

Research Areas

Neuroscience