LRP6(Phospho Thr1479) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or| with Frizzled| a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation| proliferation| and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human LRP6 (Phospho Thr1479)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

177430

synonyms

LRP6 ;Phospho Thr1479; Low-density lipoprotein receptor-related protein 6; LRP-6