LRP1 Antibody

Size

100ul

Clone Number

Aliases

A2MR antibody; Alpha 2 macroglobulin receptor antibody; alpha 2MR antibody; Alpha-2-macroglobulin receptor antibody; APOER antibody; Apolipoprotein E receptor antibody; APR antibody; CD 91 antibody; CD91 antibody; CD91 antigen antibody; IGFBP3R antibody; LDL receptor related protein 1 antibody; Low density lipoprotein receptor related protein 1 antibody; Low density lipoprotein related protein 1 antibody; Low-density lipoprotein receptor-related protein 1 intracellular domain antibody; LRP 1 antibody; LRP 515 antibody; LRP 85 antibody; LRP antibody; LRP ICD antibody; LRP-1 antibody; LRP-515 antibody; LRP-85 antibody; Lrp1 antibody; LRP1 protein antibody; LRP1_HUMAN antibody; LRP1A antibody; LRP515 antibody; LRP85 antibody; LRPICD antibody; MGC88725 antibody; Prolow density lipoprotein receptor related protein 1 antibody; TbetaR V/LRP 1/IGFBP 3 receptor antibody; TbetaRV/LRP1/IGFBP3 receptor antibody; TGFBR 5 antibody; TGFBR5 antibody; Type V tgf beta receptor antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q07954

Immunogen

Peptide sequence from Human Prolow-density lipoprotein receptor-related protein 1 protein (3924-3942AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

Background

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LRP1

Research Areas

Neuroscience; Cancer; Cardiovascular; Cell biology; Metabolism; Signal transduction