LPAR1 Antibody

Size

100ug

Clone Number

Aliases

5031439C20 antibody; AI326300 antibody; EDG 2 antibody; EDG2 antibody; Endothelial differentiation gene 2 antibody; Endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 2 antibody; GPCR 26 antibody; Gpcr26 antibody; Gpcr91 antibody; GPR26 antibody; Kdt2 antibody; LPA 1 antibody; LPA receptor 1 antibody; LPA receptor EDG2 antibody; LPA-1 antibody; lpA1 antibody; Lpar1 antibody; LPAR1_HUMAN antibody; Lysophosphatidic acid receptor 1 antibody; Lysophosphatidic acid receptor Edg-2 antibody; Lysophosphatidic acid receptor EDG2 antibody; MGC105279 antibody; MGC29102 antibody; Mrec1.3 antibody; rec.1.3 antibody; Ventricular zone gene 1 antibody; vzg-1 antibody; VZG1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q92633

Immunogen

Recombinant Human Lysophosphatidic acid receptor 1 protein (316-364AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LPAR1

Research Areas

Cardiovascular; Metabolism; Signal transduction