LONP1 Antibody

Size

100ug

Clone Number

Aliases

hLON antibody; hLON ATP dependent protease antibody; LON antibody; lon peptidase 1, mitochondrial antibody; LON protease antibody; Lon protease homolog antibody; Lon protease like protein antibody; Lon protease-like protein antibody; LONHs antibody; LONM_HUMAN antibody; LONP antibody; Lonp1 antibody; MGC1498 antibody; mitochondrial antibody; Mitochondrial ATP dependent protease Lon antibody; Mitochondrial ATP-dependent protease Lon antibody; Mitochondrial lon peptidase 1 antibody; PIM1 antibody; Protease serine 15 antibody; PRSS15 antibody; Serine protease 15 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P36776

Immunogen

Recombinant Human Lon protease homolog, mitochondrial protein (614-959AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LONP1

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Metabolism