LIMK-2(Phospho Thr505) Polyclonal Antibody

Ab type

Primary antibody

Background

There are approximately 40 known eukaryotic LIM proteins| so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA| the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK| a downstream effector of Rho| and the encoded protein| in turn| phosphorylates cofilin| inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human LIMK-2 (phospho Thr505)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

72232

synonyms

LIM domain kinase 2; LIMK2; LIM domain kinase 2; LIMK-2