LIG3 Antibody

Size

100ug

Clone Number

Aliases

D11Wsu78e antibody; DNA ligase antibody; DNA ligase 3 antibody; DNA ligase III antibody; DNLI3_HUMAN antibody; LIG 3 antibody; LIG2 antibody; LIG3 antibody; Ligase II; DNA; ATP dependent antibody; Ligase III DNA ATP dependent antibody; MGC78176 antibody; OTTMUSP00000000875 antibody; Polydeoxyribonucleotide synthase [ATP] 3 antibody; Polydeoxyribonucleotide synthase [ATP] antibody; Polydeoxyribonucleotide synthase antibody; RP23-316C11.6 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P49916

Immunogen

Recombinant Human DNA ligase 3 protein (809-928AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LIG3

Research Areas

Epigenetics and Nuclear Signaling