LGMN Antibody

Size

100ug

Clone Number

Aliases

AEP antibody; Asparaginyl endopeptidase antibody; cysteine 1 antibody; Cysteine protease 1 antibody; EC 3.4.22.34 antibody; Legumain antibody; LGMN antibody; LGMN_HUMAN antibody; LGMN1 antibody; Protease antibody; Protease cysteine 1 (legumain) antibody; Protease cysteine 1 antibody; PRSC1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q99538

Immunogen

Recombinant Human Legumain protein (199-312AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:500-1:1000

Background

Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LGMN

Research Areas

Cancer; Cell biology; Immunology; Metabolism; Signal transduction