LEF1 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

DKFZp586H0919 antibody; FLJ46390 antibody; LEF 1 antibody; LEF-1 antibody; Lef1 antibody; LEF1_HUMAN antibody; Lymphoid enhancer binding factor 1 antibody; Lymphoid enhancer-binding factor 1 antibody; T cell specific transcription factor 1 alpha antibody; T cell-specific transcription factor 1-alpha antibody; TCF 1 alpha antibody; TCF1 alpha antibody; TCF1-alpha antibody; TCF10 antibody; TCF1alpha antibody; TCF7L3 antibody; Transcription factor T cell specific 1 alpha antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UJU2

Immunogen

Recombinant Human Lymphoid enhancer-binding factor 1 protein (75-216AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LEF1

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Developmental biology; Stem cells