Lck BP-1(Phospho Tyr378) Polyclonal Antibody

Ab type

Primary antibody

Background

developmental stage:Expressed in early stage of myeloid and erythroid differentiation.,Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.,PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells.,Contains 1 SH3 domain.,Contains 4 cortactin repeats.,subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3.,tissue specificity:Expressed only in tissues and cells of hematopoietic origin.,

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human Lck BP-1 (phospho Tyr378)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

53998

synonyms

Hematopoietic lineage cell-specific protein; HCLS1; HS1; Hematopoietic lineage cell-specific protein; Hematopoietic cell-specific LYN substrate 1; LckBP1; p75