LC3 A/B Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

Probably involved in formation of autophagosomal vacuoles (autophagosomes).|PTM:The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form| LC3-I. This is activated by APG7L/ATG7| transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form| LC3-II.|Belongs to the MAP1 LC3 family.|subcellular location:LC3-II binds to the autophagic membranes.|subunit:3 different light chains| LC1| LC2 and LC3| can associate with MAP1A and MAP1B proteins.|tissue specificity:Most abundant in heart| brain| liver| skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.|

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human LC3 A/B

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

13310

synonyms

LC3 A/B