LAPTM4B Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

LAPTM4B antibody; PSEC0001 antibody; Lysosomal-associated transmembrane protein 4B antibody; Lysosome-associated transmembrane protein 4-beta antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q86VI4

Immunogen

Recombinant Human Lysosomal-associated transmembrane protein 4B protein (174-226AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LAPTM4B

Research Areas

Cancer