LAMTOR5 Antibody

Size

100ul

Clone Number

Aliases

HBV X interacting protein antibody; HBV X-interacting protein antibody; HBX interacting protein antibody; HBX-interacting protein antibody; hbxip antibody; HBXIP_HUMAN antibody; Hepatitis B virus X interacting protein antibody; Hepatitis B virus X-interacting protein antibody; LAMTOR5 antibody; Late endosomal/lysosomal adaptor MAPK and MTOR activator 5 antibody; MGC71071 antibody; Ragulator complex protein LAMTOR5 antibody; XIP antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O43504

Immunogen

Recombinant Human Ragulator complex protein LAMTOR5 protein (1-91AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LAMTOR5

Research Areas

Cell biology; Immunology