LAMTOR3 Antibody

Size

100ul

Clone Number

Aliases

LAMTOR3 antibody; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3 antibody; LTOR3_HUMAN antibody; MAP2K1IP1 antibody; MEK binding partner 1 antibody; MEK partner 1 antibody; MEK-binding partner 1 antibody; Mitogen activated protein kinase kinase 1 interacting protein 1 antibody; Mitogen-activated protein kinase kinase 1-interacting protein 1 antibody; Mitogen-activated protein kinase scaffold protein 1 antibody; Mp1 antibody; Ragulator complex protein LAMTOR3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UHA4

Immunogen

Recombinant Human Ragulator complex protein LAMTOR3 protein (1-124AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

LAMTOR3

Research Areas

Signal transduction