Lamin A/C(Phospho Ser392) Polyclonal Antibody

Ab type

Primary antibody

Background

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis| the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability| chromatin structure and gene expression. Vertebrate lamins consist of two types| A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy| familial partial lipodystrophy| limb girdle muscular dystrophy| dilated cardiomyopathy| Charcot-Marie-Tooth disease| and Hutchinson-Gilford progeria syndrome.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human Lamin A/C around the phosphorylation site of Ser392. AA range:361-410

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

74139

synonyms

Prelamin-A/C; LMNA; LMN1; Prelamin-A/C