KSR2 Antibody, FITC conjugated

Size

100ug

Clone Number

Aliases

FLJ25965 antibody; hKSR 2 antibody; hKSR2 antibody; Kinase suppressor of Ras 2 antibody; KSR 2 antibody; Ksr2 antibody; KSR2_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q6VAB6

Immunogen

Recombinant Human Kinase suppressor of Ras 2 protein (159-296AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

Background

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

FITC

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

KSR2

Research Areas

Signal transduction