KPNA6 Antibody

Size

100ul

Clone Number

Aliases

FLJ11249 antibody; IMA7_HUMAN antibody; Importin alpha 7 subunit antibody; Importin alpha S2 antibody; Importin subunit alpha 7 antibody; Importin subunit alpha-7 antibody; IPOA 7 antibody; IPOA7 antibody; Karyopherin alpha 6 antibody; Karyopherin alpha 6 (importin alpha 7) antibody; Karyopherin subunit alpha 6 antibody; Karyopherin subunit alpha-6 antibody; KPNA 6 antibody; KPNA 7 antibody; Kpna6 antibody; KPNA7 antibody; MGC17918 antibody; OTTHUMP00000004532 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O60684

Immunogen

Recombinant Human Importin subunit alpha-7 protein (277-536AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

KPNA6

Research Areas

Signal transduction