KPNA2 Antibody

Size

100ug

Clone Number

Aliases

IMA1_HUMAN antibody; Importin alpha 1 antibody; Importin alpha 2 antibody; Importin alpha 2 subunit antibody; Importin alpha P1 antibody; Importin subunit alpha-1 antibody; IPO A1 antibody; IPOA 1 antibody; IPOA1 antibody; Karyopherin alpha 2 antibody; Karyopherin alpha 2 RAG cohort 1 antibody; Karyopherin alpha 2 subunit antibody; Karyopherin subunit alpha-2 antibody; KPNA2 antibody; KPNA2 protein antibody; Pendulin antibody; QIP 2 antibody; QIP2 antibody; RAG cohort 1 antibody; RAG cohort protein 1 antibody; RCH 1 antibody; RCH1 antibody; SRP 1 antibody; SRP1 alpha antibody; SRP1 antibody; SRP1-alpha antibody; SRP1alpha antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P52292

Immunogen

Recombinant Human Importin subunit alpha-1 protein (2-285AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

KPNA2

Research Areas

Immunology; Signal transduction