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ABCbiolab
SKU:ABCE07123
(KO Validated) ADRBK1 Polyclonal Antibody
(KO Validated) ADRBK1 Polyclonal Antibody
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$445.00 USD
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Dilution
WB 1:500-1:2000 IHC 1:50-1:200
Product Details
| Isotype | IgG |
| Concentration | 1mg/mL |
| Storage | Store at -20°C. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
Immunogen Details
| Immunogen | Recombinant fusion protein of human ADRBK1 (NP_001610.2). |
| Abbre | ADRBK1 |
| Synonyms | GRK2,ADRBK1,BARK1,BETA-ARK1 |
| Swissprot | P25098 |
| Gene ID | 156 |
| Calculated MW | 79kDa |
| Observed MW | 80kDa |
| Cellular Localization | Cytosol,Plasma Membrane,Other locations:cilium,cytoplasm,membrane |
| Tissue Specificity | Expressed in peripheral blood leukocytes. |
Background
| The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. |
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