KMT2E Antibody

Size

100ul

Clone Number

Aliases

HDCMC04P antibody; Histone lysine N methyltransferase MLL5 antibody; Histone-lysine N-methyltransferase MLL5 antibody; KMT2E antibody; Lysine N methyltransferase 2E antibody; Lysine N-methyltransferase 2E antibody; MGC70452 antibody; Mll5 antibody; MLL5_HUMAN antibody; Myeloid/lymphoid or mixed lineage leukemia 5 (trithorax homolog; Drosophila) antibody; Myeloid/lymphoid or mixed lineage leukemia 5 antibody; Myeloid/lymphoid or mixed lineage leukemia protein 5 antibody; Myeloid/lymphoid or mixed-lineage leukemia protein 5 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8IZD2

Immunogen

Recombinant Human Histone-lysine N-methyltransferase 2E protein (182-316AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Histone methyltransferase that specifically mono- and dimethylates \'Lys-4\' of histone H3 (H3K4me1 and H3K4me2). H3 \'Lys-4\' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

KMT2E

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Developmental biology; Stem cells