KMT2B Antibody

Size

100ul

Clone Number

Aliases

Histone-lysine N-methyltransferase 2B antibody; HRX2 antibody; KIAA0304 gene product antibody; KMT2B antibody; KMT2B_HUMAN antibody; Likely ortholog of mouse WW domain binding protein 7 antibody; Lysine N-methyltransferase 2B antibody; mixed lineage leukemia 4 antibody; Mixed lineage leukemia gene homolog 2 protein antibody; MLL2 antibody; myeloid lymphoid leukemia 4 antibody; Myeloid lymphoid or mixed lineage leukemia protein 4 antibody; Myeloid/lymphoid or mixed-lineage leukemia protein 4 antibody; Trithorax homolog 2 antibody; trithorax homologue 2 antibody; TRX2 antibody; WBP-7 antibody; WBP7 antibody; WW domain-binding protein 7 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UMN6

Immunogen

Recombinant Human Histone-lysine N-methyltransferase 2B protein (145-290AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Histone methyltransferase. Methylates \'Lys-4\' of histone H3. H3 \'Lys-4\' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

KMT2B

Research Areas

Epigenetics and Nuclear Signaling