KMO Antibody

Size

100ul

Clone Number

Aliases

dJ317G22.1 antibody; kmo antibody; KMO_HUMAN antibody; Kynurenine 3 hydroxylase antibody; Kynurenine 3 monooxygenase (kynurenine 3 hydroxylase) antibody; Kynurenine 3 monooxygenase antibody; Kynurenine 3-hydroxylase antibody; Kynurenine 3-monooxygenase antibody; RP1-317G22.1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O15229

Immunogen

Recombinant Human Kynurenine 3-monooxygenase protein (1-260AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

Background

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

KMO

Research Areas

Metabolism; Signal transduction