KLRK1 Antibody

Size

100ug

Clone Number

Aliases

CD314 antibody; CD314 antigen antibody; D12S2489E antibody; Killer cell lectin like receptor subfamily K member 1 antibody; Killer cell lectin-like receptor subfamily K member 1 antibody; KLR antibody; KLRC4 KLRK1 readthrough antibody; KLRK1 antibody; NK cell receptor D antibody; NK lectin-like receptor antibody; NKG2 D activating NK receptor antibody; NKG2 D type II integral membrane protein antibody; NKG2-D antibody; NKG2-D type II integral membrane protein antibody; NKG2-D-activating NK receptor antibody; Nkg2d antibody; NKG2D_HUMAN antibody; NKLLR antibody; NKR P2 antibody; Nkrp2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P26718

Immunogen

Recombinant Human NKG2-D type II integral membrane protein (73-216AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

KLRK1

Research Areas

Immunology