KLB Antibody

Size

100ug

Clone Number

Aliases

Beta-klotho antibody; BetaKlotho antibody; BKL antibody; KLB antibody; KLOTB_HUMAN antibody; Klotho beta like protein antibody; Klotho beta-like protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q86Z14

Immunogen

Recombinant Human Beta-klotho protein (1-130AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

Background

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

KLB

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism; Signal transduction