KDM6A Antibody

Size

100ug

Clone Number

Aliases

bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX) antibody; bA386N14.2 antibody; bA386N14.2 ubiquitously transcribed X chromosome tetratricopeptide repeat protein UTX antibody; DKFZp686A03225 antibody; Histone demethylase UTX antibody; KABUK2 antibody; Kdm6a antibody; KDM6A_HUMAN antibody; Lysine (K) specific demethylase 6A antibody; Lysine K specific demethylase 6A antibody; Lysine specific demethylase 6A ubiquitously transcribed tetratricopeptide repeat gene X chromosome antibody; Lysine-specific demethylase 6A antibody; MGC141941 antibody; Ubiquitously transcribed tetratricopeptide repeat X chromosome antibody; Ubiquitously transcribed tetratricopeptide repeat protein X linked antibody; Ubiquitously transcribed TPR gene on the X chromosome antibody; Ubiquitously transcribed TPR protein on the X chromosome antibody; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein antibody; Ubiquitously-transcribed TPR protein on the X chromosome antibody; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein antibody; UTX antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O15550

Immunogen

Recombinant Human Lysine-specific demethylase 6A protein (620-749AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background

Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

KDM6A

Research Areas

Epigenetics and Nuclear Signaling