KDM2B Antibody

Size

100ug

Clone Number

Aliases

[Histone-H3]-lysine-36 demethylase 1B antibody; CXXC-type zinc finger protein 2 antibody; CXXC2 antibody; F box and leucine rich repeat protein 10 antibody; F box protein FBL10 antibody; F-box and leucine-rich repeat protein 10 antibody; F-box protein FBL10 antibody; F-box/LRR-repeat protein 10 antibody; Fbl10 antibody; FBXL10 antibody; JEMMA (Jumonji domain EMSY interactor methyltransferase motif) protein antibody; JHDM1B antibody; JmjC domain-containing histone demethylation protein 1B antibody; Jumonji C domain containing histone demethylase 1B antibody; Jumonji domain-containing EMSY-interactor methyltransferase motif protein antibody; kdm2b antibody; KDM2B_HUMAN antibody; Lysine (K) specific demethylase 2B antibody; Lysine-specific demethylase 2B antibody; PCCX2 antibody; Protein containing CXXC domain 2 antibody; Protein JEMMA antibody; Protein-containing CXXC domain 2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8NHM5

Immunogen

Recombinant Human Lysine-specific demethylase 2B protein (1274-1336AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Histone demethylase that demethylates \'Lys-4\' and \'Lys-36\' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 \'Lys-4\' and dimethylated H3 \'Lys-36\' residue while it has weak or no activity for mono- and tri-methylated H3 \'Lys-36\'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

KDM2B

Research Areas

Epigenetics and Nuclear Signaling