KCNC3 Antibody

Size

100ug

Clone Number

Aliases

Kcnc3 antibody; KCNC3_HUMAN antibody; KSHIIID antibody; KV3.3 antibody; Potassium voltage gated channel Shaw related subfamily member 3 antibody; Potassium voltage gated channel subfamily C member 3 antibody; Potassium voltage-gated channel subfamily C member 3 antibody; SCA13 antibody; Shaw related subfamily, member 3 antibody; Shaw related voltage gated potassium channel protein 3 antibody; Spinocerebellar ataxia 13 antibody; Voltage gated potassium channel protein KV3.3 antibody; Voltage gated potassium channel subunit Kv3.3 antibody; Voltage-gated potassium channel subunit Kv3.3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q14003

Immunogen

Recombinant Human Potassium voltage-gated channel subfamily C member 3 protein (638-745AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

Background

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

KCNC3

Research Areas

Neuroscience